Table 2.
Oral Glucose Tolerance Test
| Group | Ameroid, mg/dL | EV Injection, mg/dL | Harvest, mg/dL | |||
|---|---|---|---|---|---|---|
| Mean BG | SEM | Mean BG | SEM | Mean BG | SEM | |
| CON | ||||||
| Baseline | 138.17 | 16.34 | 131.50 | 12.83 | 128.00 | 5.45 |
| 30 min | 233.67 | 16.78 | 251.83 | 8.37 | 267.50 | 9.55 |
| 60 min | 206.33 | 21.02 | 196.67 | 8.40 | 217.83 | 8.97 |
| HVM | ||||||
| Baseline | 130.38 | 5.58 | 117.75 | 5.88 | 133.00 | 5.79 |
| 30 min | 239.63 | 15.34 | 253.00 | 9.57 | 256.63 | 5.84 |
| 60 min | 197.25 | 9.51 | 187.75 | 9.56 | 204.63 | 6.62 |
| HVMC | ||||||
| Baseline | 113.40 | 4.07 | 132.80 | 9.75 | 125.20 | 7.76 |
| 30 min | 220.00 | 12.94 | 229.80 | 9.37 | 256.00 | 10.57 |
| 60 min | 158.20 | 18.94 | 178.20 | 8.78 | 210.20 | 16.32 |
Data are given as BG level±SEM (mg/dL) after IV injection of 0.5 mg/kg of 50% dextrose. Data were analyzed using ANOVA and Kruskal‐Wallis, with P<0.05 considered as significant. BG indicates blood glucose; CON, control group (high‐fat diet with vehicle injection); EV, extracellular vesicle; HVM, high‐fat diet with myocardial EV injection group; HVMC, HVM and calpain inhibition group.