Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Jul 31;8(15):e012047. doi: 10.1161/JAHA.119.012047

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley.

This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.

PMC Copyright notice

Schematic illustration of the cardioprotective effect of MURC (muscle‐restricted coiled‐coil protein) deficiency in myocardial ischemia/reperfusion (I/R) injury. Intracellular signaling network including reactive oxygen species (ROS) reduction and activated antiapoptotic signaling with STAT3 (signal transducer and activator of transcription 3) phosphorylation leads to the cardioprotective effect in cardiomyocytes of MURC deficiency after I/R. Intracellular signaling modified by MURC deletion is highlighted (red). BCL2 indicates B‐cell lymphoma 2; EGR1, early growth response protein 1; DDIT4, DNA‐damage‐inducible transcript 4.