Table 1.
MRI Measurements
| Measurement | IBR‐MSC | IBR‐Placebo | DI‐MSC | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Baseline | 4 Weeks | 8 Weeks | Baseline | 4 Weeks | 8 Weeks | Baseline | 4 Weeks | 8 Weeks | |
| EDV, mL | 90.37±6.06 | 90.71±5.24 | 103.71±7.40 | 85.11±4.07 | 95.48±6.84 | 104.00±10.06 | 76.55±4.13 | 103.62±15.2 | 114.80±11.17 |
| ESV, mL | 50.85±5.75 | 52.99±4.92 | 57.20±6.13 | 47.12±3.32 | 58.46±5.24 | 57.77±8.48 | 53.70±4.03 | 76.59±13.26 | 85.01±10.51 |
| LVEF, % | 44.64%±3.46 | 42.37±2.62 | 45.75%±2.70 | 44.54%±3.18 | 38.76%±3.37 | 45.69%±3.68 | 30.05±2.10 | 27.08±1.97 | 26.53±2.47 |
| Core scar mass, g | 19.54±2.87 | 13.16±1.90 | 13.46±2.05 | 16.70±2.56 | 13.23±2.24 | 14.06±2.22 | 16.42±0.86 | 12.71±1.18 | 12.05±0.84 |
| Gray zone mass, g | 3.06±0.55 | 5.46±0.71 | 6.65±0.69 | 5.05±0.50 | 5.66±0.79 | 6.92±1.15 | 4.98±1.71 | 3.26±0.56 | 4.24±0.51 |
| LV mass, g | 77.60±3.39 | 88.63±3.29 | 107.24±3.87 | 76.82±4.47 | 91.46±3.68 | 103.38±5.50 | 21.40±1.33 | 15.96±1.69 | 16.30±1.25 |
Mean values±standard error of the mean (SEM). DI indicates direct injection; EDV, end‐diastolic volume; ESV, end‐systolic volume; IBR, implantable bioreactor; LV, left ventricular; LVEF, left ventricular ejection fraction; MSC, mesenchymal stem cell.