Table 3.
Mixed Lymphocyte Reaction
| Animal Identifier | Sex | Haplotype | Assay Direction | Mean CFSElo, % | SD |
|---|---|---|---|---|---|
| Cy0660 | Male | M3/M3 | Cy0666E→Cy0660T | Assay fail | Assay fail |
| Cy0666 | Male | M1/M3 | Cy0660E→Cy0666T | 1.42 | 0.15 |
| Cy0661 | Female | M3/M3 | Cy0674E→Cy0661T | 1.51 | 0.02 |
| Cy0674 | Female | M1/M3 | Cy0661E→Cy0674T | 1.32 | 0.07 |
| Cy0673 | Female | M1/M3 | Cy0700E→Cy0673T | 6.17 | 0.18 |
| Cy0700 | Female | M5/M6 | Cy0673E→Cy0700T | 11.03 | 1.72 |
| Cy0694 | Female | M3/M3 | Cy0695E→Cy0694T | 14.13 | 1.92 |
| Cy0695 | Female | M4/M4 | Cy0694E→Cy0695T | 16.53 | 1.96 |
| Cy0692 | Female | M2/M4 | Cy0613E→Cy0692T | 4.44 | 0.08 |
| Cy0613 | Female | NMC | Cy0692E→Cy0613T | 6.81 | 1.95 |
A summary of transplant effector/target pair mixed lymphocyte reaction detection is shown. Assay direction indicates effector (E) peripheral blood mononuclear cell (PBMC) proliferation to target (T); CFSE (Carboxyfluorescein succinimidyl ester); PBMC (effector PBMC→target PBMC). Animals are grouped by transplant pairs. NMC indicates non‐Mauritian cynomolgus.; CFSELo, Carboxyfluorescein succinimidyl ester low expression.