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. 2019 Sep 26;20:196. doi: 10.1186/s13059-019-1805-1

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — CpH methylation patterns across brain development. a The proportion of CAC and CAG sites that are greater than 10% methylated in neurons and non-neurons (glia) across brain development. The y-axis reflects the number of > 10% methylated CAC or CAG sites divided by the number of CAH sites in that trinucleotide context. b Autocorrelation levels for different cytosine contexts in neurons. Autocorrelation levels were similar for mCpG and all cytosines, with uncorrelated levels in the CpH context. c Euclidean distances between samples based on mCpH within cdDMRs again cluster infant neurons (dark red) with glia of all ages (light colors) rather than with older neurons