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. 2018 Nov 1;98(2):242–249. doi: 10.1177/0022034518807920

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Figure 4. — P2Y receptor activation participates in ATP-induced inward currents in hDPSCs. (A) P2X and P2Y receptors contribute to ATP-induced inward current in some hDPSCs. A1: ATP application (3 μM) induced an inward current in an hDPSC, even in the presence of blocking P2X receptors with iso-PPADS. A2: Further blockade of P2Y receptors with coapplication with suramin (100 μM) abolished the ATP-induced inward current. (B) Blocking P2X and P2Y receptors with suramin abolished ATP-induced inward currents in hDPSCs. B1: ATP-induced inward current in an hDPSC. B2: Blockade of P2X and P2Y receptors with suramin (100 μM) abolished the ATP-induced inward current. B3: After washout of suramin, the ATP-induced inward current was partially restored. (C) Immunocytochemical detection of P2Y receptors in hDPSCs: (C1) P2Y2 and (C2) P2Y6. Scale bars: 20 μm. hDPSC, human dental pulp stem cell.