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Schematic representation of negative feedback mechanisms that control endocrine system activity. In many cases, the hormones released from the target gland act back on the pituitary and/or hypothalamus, repressing further hormone release from both organs and thereby shutting off the system. For a short-loop negative feedback mechanism, pituitary hormones act directly back on the hypothalamus, inhibiting the release of hypothalamic hormones.
NOTE: ⊕ = stimulates; ⊖ = inhibits.
