Table 2.
Relationship of Lipocalin 2 to Renin-Angiotensin-Aldosterone System (RAAS), Inflammatory and Cardiac Stretch Parameters in Persons With or Without Human Immunodeficiency Virus During RAAS Activation
| Relationship to Log Lipocalin 2 (ng/mL)a | ||||
|---|---|---|---|---|
| Persons Without HIV | Persons With HIV | |||
| Parameter | r | P Value | r | P Value |
| Log plasma renin activity (ng/mL/h) | 0.18 | .63 | −0.31 | .19 |
| Log serum aldosterone (ng/dL) | 0.30 | .39 | −0.36 | .12 |
| Urine sodium (mmol/24 h) | −0.27 | .46 | 0.05 | .83 |
| Serum creatinine (mg/dL) | −0.11 | .77 | 0.19 | .42 |
| eGFR (mL/min/1.73) | 0.24 | .50 | −0.15 | .54 |
| Log IL-6 (pg/mL) | 0.14 | .71 | 0.36 | .12 |
| Log TNF-α (pg/mL) | −0.21 | .56 | 0.59 | .007 |
| Log hsCRP (mg/L) | −0.01 | .97 | 0.24 | .32 |
| Log sCD163 (ng/mL) | −0.14 | .69 | 0.61 | .005 |
| Log CCL-2 (pg/mL) | −0.37 | .29 | 0.49 | .03 |
| Log ANP (pg/mL) | 0.10 | .80 | −0.01 | .96 |
| Log BNP (pg/mL) | 0.20 | .58 | 0.69 | <.001 |
| Log NT-proBNP (pg/mL) | −0.15 | .68 | 0.68 | .001 |
Abbreviations: ANP, atrial natriuretic peptide; BNP, brain natriuretic peptide; CCL-2, chemokine (C-C motif) ligand 2; eGFR, estimated glomerular filtration rate; HIV, human immunodeficiency virus; hsCRP, high-sensitivity C-reactive protein; IL-6, interleukin 6; NT-proBNP, N-terminal fragment of the prohormone BNP; sCD163, soluble CD163; TNF-α, tumor necrosis factor α.
aRelationships were assessed based on Pearson correlation coefficients.