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Schematic diagram of the role of Slit1 in the communication between neurons and SGCs. After peripheral nerve injury, neurons activate perineuronal SGCs, leading to upregulation of Slit1 expression through the VNUT-ATP-P2X7R pathway, and SGCs then promote the regeneration of injured neurons through the Slit1-Robo2-srGAP3 pathway (Zhang et al., 2010; Chen et al., 2012b).
