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. 2019 Aug 11;220(9):1477–1488. doi: 10.1093/infdis/jiz322

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© The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 6. — Candidalysin-induced immunopathology is required for virulence during hematogenously disseminated candidiasis. (A) Survival of immunocompetent mice after intravenous inoculation with 2 × 10⁵ yeast phase cells of the indicated strains of Candida albicans (n = 10). (B) Survival of leukopenic mice infected with 5 × 10⁴ wild-type or ece1Δ/Δ C albicans yeast. Statistical significance is indicated by **, P < .01 (wild-type vs ece1Δ/Δ) and ****, P < .0001 (ece1Δ/Δ+ECE1 vs ece1Δ/Δ+ECE1_Δ184–279) (Wilcoxon rank-sum test). (C) Fungal burden of the kidney, brain, spleen, and liver of leukopenic mice at 4 days postinfection after inoculation with 5 × 10⁴ wild-type or ece1Δ/Δ C albicans yeast. Results are median ± interquartile range with 6 mice per strain. Statistical significance is indicated by **, P < .01 (Mann-Whitney test). (D) Histopathology of the pelvis region (top, lower magnification; bottom, higher magnification) of the kidney of leukopenic mice after 4 days of infection with 5 × 10⁴C albicans cells of the indicated strains. Sections were stained with Gomori methenamine silver. Scale bars = 200 µm. CFU, colony-forming units.