Table 3.
Associations of parental ages at childbirth with aging outcomes, Women’s Health Initiative
| Healthy survival to age 90 vs. usual survival to age 90a | Death before age 90 vs. usual survival to age 90 | |||
|---|---|---|---|---|
| No. survived to age 90 with healthy aging/total (%) | Multivariable-adjustedb,c OR (95% CI) |
No. died before age 90/total (%) | Multivariable-adjustedb,c OR (95% CI) |
|
| Maternal age at childbirth, years | ||||
| <25 | 969/2833 (34.2) | 1.09 (0.96–1.24) | 208/2833 (7.3) | 0.90 (0.71–1.14) |
| 25–29 | 920/2809 (32.8) | 1.00 | 216/2809 (7.7) | 1.00 |
| 30–34 | 600/1795 (33.4) | 1.00 (0.87–1.16) | 151/1795 (8.4) | 1.13 (0.88–1.46) |
| ≥35 | 460/1396 (33.0) | 1.02 (0.87–1.19) | 98/1396 (7.0) | 0.88 (0.66–1.18) |
| Paternal age at childbirth, years | ||||
| <25 | 420/1218 (34.5) | 1.15 (0.97–1.37) | 96/1218 (7.9) | 0.94 (0.69–1.29) |
| 25–29 | 863/2558 (33.7) | 1.14 (0.99–1.30) | 186/2558 (7.3) | 0.87 (0.68–1.13) |
| 30–34 | 690/2163 (31.9) | 1.00 | 173/2163 (8.0) | 1.00 |
| ≥35 | 885/2614 (33.9) | 1.15 (1.00–1.32) | 193/2614 (7.4) | 0.95 (0.74–1.22) |
CI, confidence interval; OR, odds ratio.
a
Healthy survival defined as: survival to age 90 without major morbidities (coronary heart disease, stroke, cancer, diabetes, or hip fracture) or mobility disability.
b
Multivariable model adjusted for adjusted for age, race/ethnicity, study component (Observational Study or Clinical Trial), education, income, marital status, smoking, alcohol consumption, diet quality, body mass index, depressive symptoms, physical activity, and self-rated health.
c
P-values for trend (maternal age): 0.26 (healthy survival); 0.67 (death); P-values for trend (paternal age): 0.87 (healthy survival); 0.65 (death).