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. 2001 Feb 15;21(4):1087–1095. doi: 10.1523/JNEUROSCI.21-04-01087.2001

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Copyright © 2001 Society for Neuroscience

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Fig. 1. — NO reduces neurotransmitter release at the frog neuromuscular junction. A, Time course of changes in EPP amplitude (millivolts) before, during, and after bath application of SNAP (50 μm). The horizontal barrepresents the period of exposure to SNAP. The effects of SNAP started after 5 min and were complete by 20 min. There was no recovery, even after removal of SNAP from the perfusion. Similar results were obtained in 10 experiments. B, Left, Histogram of the mean ± SEM (n = 5) of MEPP frequency in control (open bar) and after a 30 min exposure to SNAP (filled bar). Right, Histogram of the mean ± SEM of MEPP amplitude in control (open bar) and after a 30 min exposure to SNAP (filled bar). Note that SNAP significantly reduced MEPP frequency, whereas it had no effect on MEPP amplitude (*p < 0.05, Student's one-tail paired t test).