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The D164N mutant CB1 receptor is not constitutively active but can be activated by a cannabinoid agonist.A, Bar graph of the Ca2+ current inhibition in the presence of the cannabinoid agonist WIN 55,212-2 (1 μm) in neurons that were injected with CB1 or CB1-D164N cDNA (100 ng/μl). B, Bar graph of the increase in the Ca2+ current by the CB1 inverse agonist SR 141716A in neurons that were injected with wild-type CB1 or CB1-D164N cDNA (100 ng/μl). *p < 0.05 relative to the CB1 receptor.
