Fig. 2.

Time course of changes in paw withdrawal latencies after unilateral CFA injection. A clear reduction in the withdrawal response latency to nociceptive heat stimulation was observed in the CFA-injected paw. Comparison of withdrawal latencies of the CFA-injected ipsilateral paw with the noninjected contralateral paw were performed using ANOVA and Bonferroni's post hoctesting on selected groups (that is between means for ipsilateral and contralateral groups at each time point). This revealed a significant reduction within 5 hr after CFA injection that persisted until 9 d after injection: *p < 0.05; **p < 0.011; ***p < 0.001.