Table 1.

Total number and numerical density of granule cells (GCs), and volume of granule cell layer (GCL) and molecular layer (ML), in the dentate gyrus of 2-month-old wild-type and p35−/− mice

Morphological parameters	Wild-type mouse (n = 4)	p35−/− mouse ( n = 7)
Granule cell number (N × 105) in:
Granule cell layer	1.98  ± 0.16	1.77  ± 0.12
Molecular layer	0.33  ± 0.06	0.75  ± 0.06* (p <0.001)
Total number of GCs	2.32  ± 0.12	2.52  ± 0.14
Volume (Vol) of:
Granule cell layer (μm3 × 108)	5.71  ± 0.39	5.34  ± 0.38
Molecular layer (μm3 × 109)	1.57  ± 0.03	1.39  ± 0.06* (p <0.016)
Total volume (μm3 × 109)	2.14  ± 0.02	1.93  ± 0.09
Numerical density (Nv) of GCs in:
Granule cell layer (×104/μm3)	3.48  ± 0.23	3.31  ± 0.08
Molecular layer (×104/μm3)	0.21  ± 0.04	0.54  ± 0.04* (p <0.0001)
Total GC density (×104/μm3)	3.69  ± 0.22	3.85  ± 0.11

Data are expressed as mean ± SEM values.

^*Significant difference between wild-type and p35−/− mice.