Fig. 9.
Ionic mechanisms of bursting. A, Tracings show intensification of bursting and spike adaptation by progressively increasing GK-Ca inhibition during injection of 11 pA current steps. StrongerGK-Ca inhibition is needed to generate bursting when GNa-r is set to zero. No bursting is generated when GNa-p andGK-slow are turned off, butGNa-r is left active. B, Ionic currents and [Ca2+] changes during bursting elicited with IK-Ca reduction to 37% of its normal value. Note that IK-slow andINa-p are greatly enhanced during bursting compared with repetitive firing.