Table 1.

Voltage-dependent conductance parameters

Conductance state variables	n	Gmax(S/cm2)	Vrev (mV)	α (sec−1)	β (sec−1)
gNa-f
Activation	3	0.013	87.39	0.9(V + 19)/(1 − exp(−(V + 19)/10))	36 exp(−0.055(V + 44))
Inactivation	1			0.315 exp(−0.3(V + 44))	4.5/(1 + exp(−(V + 11)/5))
gNa-r
Activation	1	5e−4	87.39	0.00024 − 0.015(V − 4.5)/((exp(−(V − 4.5)/6.8) − 1))	0.14 + 0.047(V + 44)/(exp((V + 44)/0.11) − 1))
Inactivation	1			0.96*exp(−(V + 80)/62.5)	0.03*exp((V + 83.3)/16.1)
gNa-p
Activation	1	2e−4	87.39	0.091(V + 42)/(1 − exp(−(V + 42)/5))	−0.062(V + 42)/(1 − exp((V + 42)/5))
				x∞ = 1/(1 + exp(−(V + 42)/5))
				τ∞ = 5/(α + β)
gK-V
Activation	4	0.003	−84.69	0.13(V + 25)/(1 − exp(−(V + 25)/10))	1.69 exp(−0.0125(V + 35))
gK-A
Activation	3	0.004	−84.69	14.67/(1 + exp(−(V + 9.17)/23.32))	2.98(exp(−(V + 18.28)/19.47))
Inactivation	1			0.33/(1 + exp((V + 111.33)/12.84))	0.31/(1 + exp(−(V + 49.95)/8.9))
				x∞ = 1/(1 + exp(−(V + 46.7)/19.8))
				y∞ = 1/(1 + exp((V + 78.8)/8.4))
gK-IR
Activation	1	9e−4	−84.69	0.4 exp(−0.041(V + 83.94))	0.51 exp(0.028(V + 83.94))
gK-Ca
Activation	1	0.004	−84.69	2.5/(1 + 1.5e − 3/[Ca] exp(−0.085V))	1.5/(1 + [Ca]/(0.15e − 3 exp(−0.085V)))
gCa
Activation	2	4.6e−4	129.33	0.15 exp(0.063 (V + 29.06))	0.089 exp(−0.039(V + 18.66))
Inactivation	1		*	0.0039 exp(−0.055(V + 48))	0.0039 exp(0.012(V + 48))
gK-slow
Activation	1	3.5e−4	−84.69	0.008 exp(0.025(V + 30))	0.008 exp(−0.05(V + 30))
				x∞ = 1/(1 + exp(−(V + 30)/6))

This Table reports the equations used to calculate α_x, β_x, α_y, and β_y (see Eqs. 3 and 4) for the membrane conductances used in the model (in a few cases x_∞ andy_∞ are reported; see Eq. 9). The number of gating particles (n), maximum conductance (G_max), and ionic reversal potential (* resting value for Ca²⁺) used to calculate ionic currents are also shown.