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. 2001 Jul 1;21(13):4712–4720. doi: 10.1523/JNEUROSCI.21-13-04712.2001

Fig. 5.

Fig. 5.

Expression patterns of Math1 protein in the developing cochleae of wild-type (control) (A,C, E), Hes1-deficient (B), and Hes5-deficient (D, F) mice. A,B, Cross-sections through the midturn of P0 cochlea from control and Hes1−/− mice. In control, a single inner hair cell (arrowhead) and three outer hair cells express Math1. InHes1−/−, Math1 expression also included the extra IHCs (arrowheads). C,D, Cross-sections of the midturn E16 cochleae from control and Hes5−/− mice showing the differentiating extra hair cells (arrowheads). Note a diffuse expression of Math1 in the apical region of some cells in the GER of Hes5−/− mice (arrow). E, F, Cochlear surface preparations obtained from P0 control andHes5−/− mice. In control, one row of IHCs and three rows of OHCs express Math1. InHes5−/−, Math1 expression highlights the differentiating extra hair cells in both the organ of Corti (open arrows) and the GER (arrows). Scale bars, 20 μm.