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. 2001 Jul 1;21(13):4551–4563. doi: 10.1523/JNEUROSCI.21-13-04551.2001

Fig. 9.

Fig. 9.

Valinomycin induces mitochondrial swelling and inhibits staurosporine induced cytochrome c release in MCF-7/Casp-3 cells stably transfected with cytochrome c–EGFP. Cultures were treated with vehicle (Con; a,e), STS (b, f), Val (c,g), and STS and Val in combination (d, h). Digital images were acquired before (a–d) and 6 hr after (e–h) treatment. Exposure to STS induced a significant cytochrome c release resulting in a diffuse staining of cytoplasm and nucleus (f). Val alone induced cytochrome c release (arrowheads), as well as mitochondrial swelling (arrows) (g). Exposure to Val inhibited STS-induced cytochrome c release (h). Scale bar, 10 μm. Experiments were repeated six times with similar results.