Table 3.
Physiologic values for experiment 8 (mouse focal ischemia–intravenous MnTE-2-PyP5+ after treatment)
| Vehicle (n = 15) | MnTE-2-PyP5+ 1 mg (n = 17) | MnTE-2-PyP5+ 2 mg (n = 18) | |
|---|---|---|---|
| Preischemia body weight (gm) | 22 ± 1 | 22 ± 1 | 23 ± 1 |
| Day 1 body weight (gm) | 21 ± 1 | 21 ± 1 | 21 ± 1 |
| 10 min before ischemia | |||
| MAP (mmHg) | 78 ± 5 | 80 ± 5 | 78 ± 6 |
| Arterial pH | 7.19 ± 0.06 | 7.20 ± 0.04 | 7.19 ± 0.04 |
| PaCO2 (mmHg) | 37 ± 3 | 36 ± 3 | 37 ± 3 |
| PaO2 (mmHg) | 189 ± 27 | 183 ± 30 | 176 ± 28 |
| Pericranial temperature (°C) | 37.0 ± 0.1 | 37.0 ± 0.1 | 37.0 ± 0.1 |
| 25 min after onset of ischemia | |||
| MAP (mmHg) | 74 ± 6 | 76 ± 5 | 75 ± 6 |
| Pericranial temperature (°C) | 37.0 ± 0.1 | 37.0 ± 0.2 | 37.0 ± 0.1 |
| 10 min after termination of ischemia | |||
| MAP (mmHg) | 71 ± 5 | 72 ± 5 | 73 ± 5 |
| Pericranial temperature (°C) | 37.0 ± 0.1 | 37.0 ± 0.1 | 37.0 ± 0.1 |
All values are mean ± SD. MAP, Mean arterial pressure; PaCO2, arterial carbon dioxide partial pressure; PaO2, arterial oxygen partial pressure. There were no differences among groups.