Fig. 3.

Mean [³H]DA uptake expressed as mean percentage of counts per minute (CPM) in primary cultures of rat mesencephalic neurons. Cultures were treated with 3 μm MPP⁺, 3 μmMPP⁺, and 100 μm zVAD-fmk, or 3 μm MPP⁺ and 100 μmzIETD-fmk, and treatments were terminated after 12 (A), 24 (B), and 72 (C) hr. Mean total counts per minute per control well were 1423 ± 142 (12 hr), 10419 ± 2301 (24 hr), and 6589 ± 1610 (72 hr). *p < 0.005 compared with control cultures. +p < 0.05 compared with MPP⁺ cultures.