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. 2001 Apr 1;21(7):2256–2267. doi: 10.1523/JNEUROSCI.21-07-02256.2001

Fig. 7.

Fig. 7.

Rp-cAMPS abolishes the survival-promoting effect of cpt-cAMP but only partially inhibits the survival-promoting effect of depolarization. Spiral ganglion cultures were maintained for 48 hr in 5K or in DMEM plus N2 with one of the trophic stimuli used in Figure 5, each stimulus with or without 1 mm Rp-cAMPS. In addition, survival was assayed in 30K with Rp-cAMPS and either 20 μm PD98059 or 20 μm LY294002, or TrkB-IgG plus TrkC-IgG (each at 1 μg/ml). Survival was determined as in Figure1 and is expressed as a percentage of the number of SGNs in the 30K condition, the condition with maximal survival. Counting, plotting, and statistics are as for Figure 5. Survival in 30K plus Rp-cAMPS (single asterisk) is significantly lower than in 30K, as determined by two-tailed Student's t test (p = 0.002). The three conditions labeled with double asterisks are all significantly lower than the 30K plus Rp-cAMPS condition, as determined by two-tailed Student'st test (p < 0.04).