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PKA activator decreases the persistent Na+ current in the Nav1.6 null mice.A, Application of cBIMPS (50 μm) produced only a small decrease of the persistent Na+ current in the control mice. B, Conversely, the application of cBIMPS in the Nav1.6 null mice induced a significant reduction of the persistent Na+ current. C, Box plot summarizes the reduction of the Na+ current in the wild-type mice (n = 10) and in the Nav1.6 null mice (n = 5).
