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Bcl-XL deficiency fails to prevent neurodevelopmental abnormalities in Caspase-9-deficient embryos. Toluidine blue-stained horizontal sections from the E12.5 telencephalon show well organized neuroepithelium in wild-type (A) but neithercaspase-9−/−(B) norbcl-x−/−/caspase-9−/−(C) embryos. In both Caspase-9-deficient embryos, the telencephalic vesicle is thickened, and supernumerary cells fill the lateral ventricle (V).a, Anterior. Scale bar, 25 μm.
