Table 2.
Apoptosis in E12.5 dorsal root ganglia and liver
| Genotype (n) | Dorsal root ganglia (cells/field) | Liver (cells/field) |
|---|---|---|
| bcl-x+/*/casp9+/*(6) | 7.5 ± 1.1 | 9.9 ± 1.5 |
| bcl-x−/−/casp9+/*(6) | 17.2 ± 1.4* | 21.0 ± 1.2* |
| bcl-x+/*/casp9−/*(7) | 0.8 ± 0.4* | 10.6 ± 1.8 |
| bcl-x−/*/casp9−/* (4) | 0.7 ± 0.8* | 18.2 ± 1.4* |
Bouin's fixed sagittal sections from paraffin-embedded E12.5bcl-x+/*/casp9+/*, bcl-x−/−/casp9+/*, bcl-x+/*/casp9−/−, andbcl-x−/−/casp9−/− mice were TUNEL-labeled (* denotes + or −). The number of embryos analyzed is shown in parentheses. The mean number of positive cells and SEM per 60× field were determined for each group.
p < 0.05 versus bcl-x+/*/casp9+/*using Kruskal–Wallis ANOVA on ranks.