Fig. 1.
Effect of CORT on the modulation of [35S]TBPS binding by 100 nm THDOC in dorsal hippocampus. Male rats of mixed gonadal status received CORT pellets or vehicle pellets subcutaneously for 10 d. Data are expressed as the specific binding of [35S]TBPS in the presence of THDOC as percentage of binding in the absence of THDOC, normalized for each animal. Shown are means and error bars representing SEM; n = 27 for CORT- and vehicle-treated animals. There was an overall significant main effect of CORT treatment on the mean percentage modulation by THDOC in hippocampus (F(1,52) = 7.28; p= 0.0094), indicated by an asterisk. There were also significant regional differences between mean levels of modulation by THDOC, averaged across treatments, between CA3 stratum radiatum and CA3 stratum oriens (t = −34.65; p≤ 0.0001), and between CA3 stratum radiatum and CA1 stratum radiatum (t = −9.95; p ≤ 0.0001). See Table 3 for summary of statistical analysis.