Fig. 6.
Effect of CORT on the modulation of [3H]flunitrazepam binding by GABA in the dorsal hippocampus. Brain sections from CORT- or vehicle-treated, gonadally intact animals were incubated with 0.5 nm[3H]flunitrazepam in buffer alone or buffer containing 3 μm GABA. Data presented are [3H]flunitrazepam-specific binding in the presence of GABA, expressed as the percentage of binding in the absence of GABA. Shown are means and error bars representing SEM; n= 9. There was a significant CORT- versus vehicle-treatment effect (F(1,16) = 9.81; p= 0.0064), and a significant interaction between treatment and hippocampal region (F(1,16) = 6.23;p = 0.0239). Set B contrasts indicated that mean percentage modulation of [3H]flunitrazepam binding by GABA differed between CORT- and vehicle-treated animals in the dentate gyrus (t = −3.98; p = 0.0011), indicated by an asterisk.