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. 2001 Jan 1;21(1):84–91. doi: 10.1523/JNEUROSCI.21-01-00084.2001

Fig. 4.

Fig. 4.

Memory-impaired animals with lesions of the fornix fail to induce C/EBPβ or -δ. A, Northern blot analyses of hippocampal extracts taken from rats with fornix lesions immediately (0 h) or 9 and 20 hr after training. Autoradiograph shows mRNA levels of individual animals that either (1) underwent full training (+) or (2) entered the IA apparatus but received no shock (−). Cyclophilin was used as a control probe for normalization of both C/EBP hybridizations. B, Densitometric analysis of C/EBPβ autoradiographs shown inA. Rats with fornix lesions did not exhibit IA learning-related induction of C/EBPβ at 9 or 20 hr after training compared with unoperated, 0 h − control rats. Data are expressed as mean percentage ± SEM of the unoperated,0 h − (100%) control mean values.C, Densitometric analysis of C/EBPδ Northern blots shown in A. C/EBPδ mRNA is not induced in rats with fornix lesions after IA training compared with unoperated, 0 h − controls. Data are expressed as mean percentage ± SEM of the unoperated, 0 h − (100%) control mean values.