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. 2001 Jan 1;21(1):67–74. doi: 10.1523/JNEUROSCI.21-01-00067.2001

Fig. 6.

Fig. 6.

Graphic summary of results. Barsindicate which residues fall into each of the following categories:Mediates KD-GABA, mutation of this residue alters microscopic affinity for GABA; Mediates Efficacy, mutation of this residue reduces efficacy of P4S;Accessible to MTS, we can detect reaction of MTSEA-biotin with a cysteine introduced at this position; In Binding Pocket, the rate at which MTSEA-biotin reacts with a cysteine introduced at this residue is slowed by the presence of both GABA and SR-95531. Relative Rxn. Rate, The height of thebar is scaled to the log ofk2 for each mutant with MTSEA-biotin.