Table 1.

Amount (fmol/mg protein) of GABA_A receptors and benzodiazepine binding sites in WT, α1−/−, and β2−/− mice determined by nonlinear regression analysis of saturation data sets

	Wild type	α1−/−1-a	β2−/−1-b
Muscimol	3014  ± 274	1011  ± 241	1275  ± 210
Ro15-1788:
Forebrain (F3)	2677  ± 174	1160  ± 219	1326  ± 143
Cerebellum (F3)	1212  ± 123	419  ± 18	339  ± 34

Note that Ro15-1788 values for α1−/− derived from F3 generation mice. Data are the mean ± SEM of three or four experiments.

^F1-aAll B_max are different from wild-type p < 0.003 (t test; unpaired, two-tailed).

^F1-bAll B_max are different from wild-type p < 0.002 (t test; unpaired, two-tailed).