Table 3.

Summary of previously published SOD1 transgenic models

Transgenic line	h/m SOD1 ratio	Onset of disease	Reference
h-SOD1	1–10	No disease	(Epstein et al., 1987)
			(Ceballos-Picot et al., 1991)
			(Gurney et al., 1994)
			(Wong et al., 1995)
			(Bruijn et al., 1997)
m-SOD1 null	No SOD1	No disease	(Reaume et al., 1996)
h-G37R	10–12	3.5–4 months	(Wong et al., 1995)
	4–5	6–8 months	(Wong et al., 1995)
h-G85R	1	8–10  months	(Bruijn et al., 1997)
	0.2	12–14 months	(Bruijn et al., 1997)
m-G86R	1	3–4 months	(Ripps et al., 1995)
m-G86R	Restricted to astocytes	No disease	(Gong et al., 2000)
h-G93A	4	4–6 months	(Gurney et al., 1994)

h, Human SOD1; m, mouse SOD1 transgene.