Fig. 4.

Time course of IL-1 protein changes in the dorsal spinal cord after lumbosacral intrathecal gp120 administration. Rats were administered intrathecal gp120 (black squares) or intrathecal vehicle (black-and-white squares) either 20, 40, 60, 90, or 120 min before tissue collection. A, gp120 increased IL-1 protein in the dorsal lumbar spinal cord, relative to vehicle controls. B, Site specificity of this effect was found based on the fact that increases in IL-1 protein in the cervical spinal cord were both much lower in magnitude and slower to occur. Note that the assay units in this figure are in picograms (see Fig. 5, units in nanograms).