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. 2001 Apr 15;21(8):2808–2819. doi: 10.1523/JNEUROSCI.21-08-02808.2001

Fig. 8.

Fig. 8.

Elevations of dorsal lumbar spinal cord IL-1 and lumbosacral CSF IL-1 produced by intrathecal gp120 are both blocked by pretreatment with intrathecal TNFbp. After completion of behavioral testing (see Fig. 7), dorsal lumbar spinal cord (A) and lumbosacral CSF (B) were collected and assayed by ELISA for IL-1 protein. Relative to controls (Vehicle + Vehicle; white bar), intrathecal gp120 increased dorsal lumbar spinal cord IL-1 protein content (Vehicle + gp120; black bar). Although TNFbp had no effect in the absence of gp120 (TNF-bp + Vehicle; herringbone bar), TNFbp blocked the gp120-induced increase of IL-1 at this time (TNF-bp + gp120; striped bar).