Table 1.
Striatal [3H]WIN 35,428 binding densities in monkeys during the initial phase of cocaine self-administration1-a
| Brain regions | Control n = 6 | Cocaine 0.03 mg/kg/inj n = 4 | Percent difference1-b | Cocaine 0.3 mg/kg/inj n = 4 | Percent difference1-b |
|---|---|---|---|---|---|
| Rostral precommissural striatum | |||||
| Dorsolateral caudate | 95.1 ± 9 | 71.6 ± 5* | 25% | 79.0 ± 4 | 17% |
| Dorsomedial caudate | 116.4 ± 9 | 99.6 ± 6 | 15% | 98.5 ± 6 | 15% |
| Ventral caudate | 107.3 ± 8 | 89.5 ± 3 | 17% | 88.1 ± 7 | 18% |
| Dorsal putamen | 116.1 ± 9 | 93.2 ± 7 | 20% | 104.7 ± 9 | 10% |
| Central putamen | 107.2 ± 7 | 90.7 ± 7 | 15% | 96.9 ± 3 | 10% |
| Ventral putamen | 85.1 ± 8 | 70.8 ± 8 | 17% | 77.5 ± 4 | 9% |
| Accumbens | 56.6 ± 5 | 45.4 ± 4 | 20% | 47.7 ± 5 | 16% |
| Caudal precommissural striatum | |||||
| Dorsolateral caudate | 96.7 ± 7 | 72.1 ± 4* | 25% | 85.6 ± 10 | 12% |
| Dorsomedial caudate | 120.8 ± 6 | 103.2 ± 6 | 15% | 113.6 ± 11 | 6% |
| Ventral caudate | 88.9 ± 3 | 78.8 ± 7 | 11% | 82.9 ± 6 | 7% |
| Dorsal putamen | 110.5 ± 2 | 91.4 ± 4 | 17% | 106.2 ± 13 | 4% |
| Central putamen | 105.3 ± 3 | 85.5 ± 6* | 19% | 100.3 ± 1 | 5% |
| Ventral putamen | 88.5 ± 6 | 70.9 ± 7 | 20% | 78.0 ± 9 | 12% |
| Accumbens (shell) | 48.6 ± 5 | 38.4 ± 4 | 21% | 45.9 ± 9 | 6% |
| Accumbens (core) | 59.4 ± 4 | 49.5 ± 3 | 17% | 54.1 ± 7 | 9% |
| Olfactory tubercle | 58.3 ± 4 | 48.6 ± 6 | 17% | 53.4 ± 8 | 8% |
F1-a
Data represent femtomoles per milligram, wet weight tissue and are expressed as mean ± SEM.
F1-b
Percent difference from control values.
*
p < 0.05 different from control. Statistical analysis was performed for each brain region by means of a one-way ANOVA, followed by a post hoc LSD test comparing drug treatments to controls.
inj, Injection.