Table 2.
Striatal [3H]WIN 35,428 binding densities in monkeys during the chronic phase of cocaine self-administration2-a
| Brain regions | Control n = 6 | Cocaine 0.03 mg/kg/inj n = 4 | Percent difference2-b | Cocaine 0.3 mg/kg/inj n = 4 | Percent difference2-b |
|---|---|---|---|---|---|
| Rostral precommissural striatum | |||||
| Dorsolateral caudate | 95.1 ± 9 | 91.6 ± 8 | 4% | 97.7 ± 4 | 3% |
| Dorsomedial caudate | 116.4 ± 9 | 120.6 ± 6 | 4% | 124.1 ± 10 | 7% |
| Ventral caudate | 107.3 ± 8 | 116.2 ± 6 | 8% | 112.8 ± 6 | 5% |
| Dorsal putamen | 116.1 ± 9 | 121.4 ± 11 | 5% | 125.4 ± 7 | 8% |
| Central putamen | 107.2 ± 7 | 121.1 ± 9 | 13% | 116.7 ± 6 | 9% |
| Ventral putamen | 85.1 ± 8 | 101.8 ± 5 | 20% | 96.7 ± 4 | 14% |
| Accumbens | 56.6 ± 5 | 73.4 ± 5* | 30% | 68.2 ± 2 | 20% |
| Caudal precommissural striatum | |||||
| Dorsolateral caudate | 96.7 ± 7 | 100.6 ± 8 | 4% | 120.7 ± 5* | 25% |
| Dorsomedial caudate | 120.8 ± 6 | 131.8 ± 7 | 9% | 145.0 ± 9* | 20% |
| Ventral caudate | 88.9 ± 3 | 107.2 ± 8* | 21% | 110.6 ± 52-160 | 25% |
| Dorsal putamen | 110.5 ± 2 | 120.2 ± 10 | 9% | 144.2 ± 92-165 | 31% |
| Central putamen | 105.3 ± 3 | 125.6 ± 11 | 19% | 134.5 ± 8* | 28% |
| Ventral putamen | 88.5 ± 6 | 111.2 ± 8* | 26% | 114.2 ± 9* | 29% |
| Accumbens (shell) | 48.6 ± 5 | 63.7 ± 3* | 31% | 74.7 ± 52-165 | 54% |
| Accumbens (core) | 59.4 ± 4 | 81.1 ± 72-160 | 37% | 86.7 ± 62-165 | 46% |
| Olfactory tubercle | 58.3 ± 4 | 82.6 ± 12-160 | 42% | 80.4 ± 12-165 | 38% |
F2-a
Data represent femtomoles per milligram, wet weight tissue and are expressed as mean ± SEM.
F2-b
Percent difference from control values.
*
p < 0.05;
F2-160: p < 0.01;
F2-165: p < 0.005 different from control. Statistical analysis was performed for each brain region by means of a one-way ANOVA, followed by a post hoc LSD test comparing drug treatments to controls.
inj, Injection.