Fig. 7.
The sensitivity of the GABAA receptor was decreased by treatment with a high concentration of vigabatrin.A, Shown is the peak response to direct application of 2 μm GABA in neurons from cultures that had been treated with 100 μm vigabatrin for 3–4 d (**p < 0.001). These are the same neurons as shown in Figures 4B and 6D.B, Treatment with 100 μm vigabatrin overnight led to a trend toward a smaller peak response to direct application of 2 μm GABA that was not statistically significant (p = 0.06). Shown is the mean response from 31 vigabatrin-treated neurons and 28 control neurons. Baseline was leak-subtracted in B. This is the same set of neurons as in Figure 6B.