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Kainate depresses the NMDA receptor-mediated EPSC.A, Averaged, stimulus-evoked NMDA receptor-mediated EPSCs are depressed by 10 μm KA in the presence of 100 μm GYKI 53655. B, The KA-induced depression is shown as a function of time under control conditions (filled circles) and in the presence of 100 μm CNQX (open circles). C, KA causes a decrease in 1/CV2 of the EPSC that is correlated with the decrease in mean EPSC amplitude. Individual experiments are shown.
