Fig. 2.

Characterization of a unitary connection between a fast-spiking cell and a pyramidal cell in layer V of the motor cortex.A, Top traces, Single sweep variation of IPSCs elicited in the pyramidal cell held at −30 mV by pairs of APs evoked in the FS cell. Bottom traces, Average IPSCs in control and in GABAzine (10 μm), a GABA_A receptor antagonist. Note that the FS to pyramidal cell connections studied in layer V of the motor cortex typically displayed synaptic depression, which was frequency-dependent. B, Current–voltage relation of the unitary IPSCs characterized by a reversal potential of −70 mV.