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. 2001 May 1;21(9):3207–3214. doi: 10.1523/JNEUROSCI.21-09-03207.2001

Fig. 2.

Fig. 2.

Behavioral parameters on the EPM of female and male rats treated with intracerebroventricular or intravenous oPRL.A, B, Acute intracerebroventricular oPRL administered 10 min before EPM exposure decreased the anxiety-related behavior in a dose-dependent manner in virgin female (A) or male (B) rats. For comparison, an anxiolytic effect could also be revealed 30 min after injection of diazepam (1 mg/kg, i.p.) in male but not female rats (insets). C, Acute intravenous oPRL administered 20 min before EPM also decreased anxiety-related behavior in female rats. The percentage of entries into (entries) and the time spent on (time) the open arms to overall arm entries and time, respectively, and the number of full entries into the open arms of the EPM are given as indicators of anxiety-related behavior. The number of entries into the closed arms (entries closed) is given as an indicator of locomotor activity. Data are the mean ± SEM. *p < 0.05, **p < 0.01 versus vehicle.