Table 1.

Behavioral characterization of rats treated with intracerebroventricular oPRL in the forced swim test (10 min, females and males) and the open field (15 min, females)

	Vehicle		Prolactin
	Female	Male	Female	Male
Forced swim	n = 8	n = 10	n = 8	n = 11
Struggling (sec)	108  ± 33.0	79.3  ± 9.9	126  ± 61.3	114  ± 12.6*
Floating (sec)	16.0  ± 15.5	12.2  ± 5.0	5.2  ± 3.2	6.8  ± 2.5
Latency (sec)	224  ± 124	167  ± 50.6	416  ± 238*	293  ± 58.9
Open field	n = 6		n = 7
Distance (cm)	5634  ± 261		4354  ± 395*

Rats were treated with oPRL [0.1 μg/5μl (swim) or 1.0 μg/5 μl (open field), i.c.v.] or vehicle (5 μl of sterile saline) 10 min before testing as described in Results. During forced swimming, the time spent struggling and floating and the latency until first floating were recorded. In the open field, the total distance traveled was monitored. Data are the means ± SEM.

^*p < 0.05 versus vehicle.