Fig. 4.

Whole-cell patch-clamp recordings of mIPSCs in stellate cells from genetically altered mice at P35. InA, slow sweeps illustrate the occurrence of mIPSCs in a wild-type mouse and in the homozygote α1 −/−. In B, the average of 50 currents is illustrated with the weighted decay time constant τ_w from a double exponential curve fit indicated. In C, the weighted time constant from the exponential fitting of the currents is compared between different genotypes. Bars indicate average values. Data were derived from at least 14 cells from at least four mice in each group. *p < 0.001, statistical significance compared with +/+ mice.