Fig. 6.

Morphometric analysis of the number (A), size (B), and percentage coverage (C) of cytoplasmic area by intact mitochondria, mitochondria with broken cristae, total mitochondria (intact plus mitochondria with broken cristae), vacuoles associated with lipofuscin, and lipofuscin in cases of AD and controls. Whereas percentage coverage of intact mitochondria decreases in AD (p = 0.012), no significant changes were noted in vacuoles associated with lipofuscin (p = 0.056), mitochondria with broken cristae (p > 0.10), or lipofuscin (p > 0.08). Although the size of lipofuscin did not change in AD (p = 0.095), that of the vacuoles associated with lipofuscin significantly increased (p = 0.029). Statistical comparison by theF test. * indicates significant difference between AD and control cases.