Fig. 2.

The nature of neuronal nAChR modulation by Zn²⁺ is subunit dependent. The effects of Zn²⁺ coapplication on Ach-induced current responses are plotted as a percentage of the response to ACh alone (mean ± SEM of 3–6 oocytes). Some error bars are obscured by the symbols. The potentiating and inhibiting phases of the Zn²⁺effect were fit separately as described in Materials and Methods. Note the increase in axis range in C to accommodate the greater potentiation seen with α4β4 nAChRs.