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Zn2+ potentiation of α4β4 is sensitive to alterations in pH. Potentiation of the response to 1 μm ACh by 100 μm Zn2+ at pH 5.5, 7.2, and 8.0 is plotted as a percentage of the response to ACh alone (mean ± SEM of 3 oocytes; significant differences from pH 7.2: *p < 0.0001, **p < 0.005).
