Fig. 8.
A–D, Actions of GABAAreceptor modulators on recombinant receptor subtypes. Modulation of GABAA α1β3γ2 (white bar), α2β3γ2 (hatched bar), and α5β3γ2 (black bar) receptors by RY (A), ZK (B), Ro 15–4513 (C), and Ro 15–1788 (D). Saturating concentrations (1–10 μm) of modulator was coapplied over voltage-clamped oocytes along with an EC50 of GABA, and the whole-cell current response in the presence of modulator is reported as a percentage of the current response to GABA alone (percent GABA response, mean ± SD of 3–4 separate oocytes except for ZK on α6β3γ2, which is 7 separate oocytes).