Table 1.
Experiment | Groups (N) | Habituation | S4 | S5 | ||||
---|---|---|---|---|---|---|---|---|
S2 | S3 | S4 | DO | NDO | DO | NDO | ||
1 | Control (13) | 26.6 ± 1.5 | 19.03 ± 1.2 | 11.2 ± 1.1 | 10.0 ± 1.2 | 11.7 ± 1.3 | 15.9 ± 1.1* | 7.6 ± 0.78 |
AP-5 0.075 (8) | 26.8 ± 2.3 | 14.9 ± 1.1 | 9.2 ± 0.8 | 8.7 ± 0.8 | 9.6 ± 0.9 | 12.6 ± 1.1*† | 6.8 ± 0.9 | |
AP-5 0.15 (8) | 24.1 ± 1.4 | 15.9 ± 1.9 | 11.4 ± 1.5 | 11.3 ± 1.6 | 11.4 ± 1.5 | 10.6 ± 1.8† | 9.1 ± 0.9 | |
AP-5 0.3 (8) | 30.7 ± 1.9 | 18.6 ± 1.3 | 12.4 ± 1.2 | 12.4 ± 1.4 | 12.4 ± 1.4 | 11.7 ± 1.6† | 11.4 ± 1.71-160 | |
2 | Control (7) | 23.1 ± 2.6 | 16.3 ± 1.5 | 11.2 ± 1.6 | 10.7 ± 1.6 | 11.5 ± 1.6 | 15.5 ± 2.1* | 7.9 ± 0.8 |
DNQX 0.001 (7) | 24.9 ± 1.3 | 17.5 ± 1.5 | 10.5 ± 0.9 | 10.0 ± 1.2 | 10.9 ± 0.8 | 16.2 ± 1.6* | 7.8 ± 1.4 | |
DNQX 0.005 (8) | 25.0 ± 0.8 | 14.7 ± 1.8 | 10.1 ± 1.4 | 10.4 ± 1.7 | 9.8 ± 1.5 | 16.2 ± 1.2* | 8.6 ± 0.6 | |
3 | Control (9) | 24.1 ± 1.2 | 13.6 ± 1.7 | 8.1 ± 1.7 | 7.5 ± 1.6 | 8.5 ± 1.7 | 15.6 ± 1.0* | 6.7 ± 0.4 |
AP-5 0.3 (8) | 23.9 ± 1.5 | 13.4 ± 1.3 | 9.6 ± 1.0 | 8.6 ± 1.3 | 10.3 ± 1.1 | 16.5 ± 1.5* | 9.9 ± 0.7 | |
DNQX 0.005 (9) | 23.3 ± 1.4 | 13.9 ± 0.9 | 7.9 ± 1.1 | 7.9 ± 1.1 | 7.7 ± 1.3 | 14.4 ± 2.2* | 5.9 ± 0.9 | |
4 | Control (8) | 21.4 ± 1.4 | 13.2 ± 1.9 | 7.8 ± 1.4 | 7.4 ± 1.7 | 7.4 ± 1.5 | 13.6 ± 1.4* | 6.1 ± 0.6 |
AP-5 0.15 (8) | 24.7 ± 2.1 | 14.8 ± 2.1 | 8.3 ± 0.9 | 7.8 ± 1.1 | 8.5 ± 0.8 | 13.4 ± 1.4* | 6.9 ± 0.8 | |
DNQX 0.001 (7) | 24.6 ± 1.7 | 16.4 ± 1.4 | 7.5 ± 0.9 | 7.2 ± 0.9 | 7.8 ± 1.1 | 3.4 ± 0.91-160 | 2.8 ± 0.81-160 | |
5 | Control (7) | 15.9 ± 0.8 | 8.7 ± 1.0 | 6.9 ± 1.2 | 6.6 ± 1.2 | 7.1 ± 1.1 | 15.1 ± 1.9* | 5.8 ± 1.0 |
DNQX 0.001 (7) | 10.6 ± 2.3 | 4.2 ± 2.2 | 1.9 ± 0.5 | 1.1 ± 0.6 | 1.3 ± 0.5 | 8.8 ± 1.0† | 8.7 ± 1.01-160 |
The duration of contact is expressed as mean per object. Mean duration of contact with the entire set of objects before the spatial change, S2–S4, and with the different object categories, DO and NDO, before (S4) and after (S5) the change.
p < 0.05 within DO group versus NDO group in S5;
F1-160: †p < 0.05 within object category saline versus drug-treated mice in S5.