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Retigabine abolishes firing in SCG neurons. Voltage responses to depolarizing and hyperpolarizing current pulses recorded from an SCG neuron before (A) and during the application of retigabine (RTG; 3 μm) (B, C). Note in C that larger depolarizing current pulses are required to evoke an action potential in the presence of retigabine. D, Action potential evoked by a 1 msec/700 pA depolarizing pulse in the presence (thick line) and absence (thin line) of retigabine (3 μm).
