Fig. 2.

Activation of heteromeric KCNQ2/3 and homomeric KCNQ2–4 channels expressed in CHO cells in the absence and presence of retigabine. Families of KCNQ currents were recorded in the absence (left) or presence (right) of 10 μm retigabine. Currents were activated by 1 sec depolarizing pulses in 10 mV increments to +50 mV from a holding potential of −70 mV. Records show currents recorded at −40, −20, 0, and +20 mV. Note that KCNQ3 and KCNQ4, but not KCNQ2/3 and KCNQ2 currents, are increased at all voltages by retigabine.