Table 1.

Potency of retigabine against KCNQ2/3, KCNQ1, KCNQ2, KCNQ3, and KCNQ4

	Maximum shift in V1/2 (mV)	Retigabine EC50 (μm)
KCNQ2/3	−30.4	1.9  ± 0.2 (n = 5)
KCNQ1	−0.7	100.1  ± 6.5 (n = 4)1-a
KCNQ2	−24.2	2.5  ± 0.6 (n = 5)
KCNQ3	−42.8	0.6  ± 0.3 (n = 3)
KCNQ4	−24.6	5.2  ± 0.9 (n = 3)

Columns show the maximum leftward shift ofV_1/2 (see Fig. 5) induced by retigabine and the corresponding EC₅₀ value for the shift for KCNQ2–4 (see Fig. 6), calculated as the mean ± SEM of the shifts produced in the individual experiments (number of experiments in parentheses). Note that 100 μm retigabine was sufficient to produce a maximum shift for KCNQ2/3, KCNQ2, and KCNQ3; for KCNQ4, 300 μm retigabine was required.

^F1-a KCNQ1, IC₅₀ for inhibition (see Fig. 7).