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Models of structural plasticity underlying the formation of multiple-synapse boutons after trace eyeblink conditioning. A, Outgrowth of newly emerging spines for specific synaptogenesis with single-synapse boutons activated by conditioning stimulation. B, Coupling of the latter process with the resorption of existing spines postsynaptic to nonactivated boutons. C, Relocation of existing spines from nonactivated boutons for specific synaptogenesis with activated single-synapse boutons.
